Progress in developing rat models of hepatic encephalopathy
نویسندگان
چکیده
منابع مشابه
Research progress on hepatic encephalopathy: animal models and disease mechanisms
Hepatic encephalopathy (HE) is a hepatic disease with neuronal confusion, altered level of consciousness, and coma as a result of severe liver damage/failure. HE is with complicated pathological mechanisms and high mortality, which seriously affects patients' daily life. Roughly, it can be divided into three types, A, B and C. Type A is acute HE and Types B and C are chronic. At present, the pa...
متن کاملExperimental models for hepatic encephalopathy.
Although there are many models for animal testing, the ideal model for chronic liver disease involving hepatic encephalopathy has not been described yet. Different problems associated with the models have led researchers to develop their own, sometimes unique experimental models, which makes difficult the comparison between the results of the conducted studies (1). Hepatic encephalopathy (HE) d...
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Patient-reported outcomes (PRO) are critical to understand the spectrum of disease in chronic conditions but are often ignored in clinical practice. Cirrhosis, one of the leading causes of morbidity, is associated with severely impaired PROs likely due to covert hepatic encephalopathy (CHE). The clinical relevance and logistic barriers to routine CHE testing led us to develop the "EncephalApp S...
متن کاملEvaluation of the role of TLR4 in endotoxin-induced hepatic encephalopathy in rats with biliary cirrhosis
Background: Hepatic encephalopathy is defined as a neuropsychiatric brain dysfunction in acute or chronic liver failure. Infection and inflammation have crucial role in its pathophysiology. The purpose of our study was to demonstrate the relationship between toll-like receptor 4 (TLR4) expression and the encephalopathy induced with endotoxin in biliary cirrhotic rats. Methods: The present stud...
متن کاملEvaluation of two experimental models of hepatic encephalopathy in rats.
The serious neuropsychological repercussions of hepatic encephalopathy have led to the creation of several experimental models in order to better understand the pathogenesis of the disease. In the present investigation, two possible causes of hepatic encephalopathy, cholestasis and portal hypertension, were chosen to study the behavioral impairments caused by the disease using an object recogni...
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ژورنال
عنوان ژورنال: World Chinese Journal of Digestology
سال: 2010
ISSN: 2219-2859
DOI: 10.11569/wcjd.v18.i30.3204